Aggravation by Clopidogrel, an Antiplatelet Drug, of Antral Lesions Induced by NSAIDs in Rats
نویسندگان
چکیده
Background/Aim: Recent studies suggested a risk of gastric adverse reaction on the concomitant use of antiplatelet drugs with NSAIDs. The present study was performed to examine the adverse effects of anti-platelet drug clopidogrel, a P2Y12 receptor antagonist, on gastric antral lesions induced by conventional NSAIDs in refed
منابع مشابه
Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.
Recent clinical studies have suggested a risk of adverse gastric reactions from the concomitant use of selective serotonin (5-HT) reuptake inhibitors (SSRIs) with nonsteroidal anti-inflammatory drugs (NSAIDs). We examined the adverse effects of SSRIs on antral lesions produced by indomethacin in rats. Rats fasted for 24 h were refed for 1 h, then administered indomethacin (30 mg/kg s.c.) 1 h af...
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